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diagnosis hematology algorithm hemolytic causes extravascular intravascular oncology agglutinin classification cold fever gap globulin hepatitis hepatology hodgkins infectiousdiseases injury liver
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... hemoglobinuria (PNH ... idiopathic) - Autoimmune ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Drug-associated, PCH ... Defects: Sickle cell anemia ... Laboratory Tests
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Cold AIHA • Alloimmune ... Cold AIHA • PCH ... • PNH ... anemia •
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... platelet decrease - PNH ... elliptocytosis, autoimmune ... #Anemia #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... - Mycoplasma, EBV ... pts) Differential ... • Diagnostic Test ... #hemolytic #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... PK, HbC, HbSS, PNH ... - Extrinsic: Autoimmune ... Non-megaloblastic: Liver disease
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... HBV, HCV, HEV, EBV ... • Autoimmune: ... Autoimmune hepatitis ... extrahepatic source - Tests
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... WAIHA • CAD • PCH ... • Coombs (-) hemolytic ... anemia due to cold ... Hematology #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate ... number of sites of disease
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
Infectious Disease ... as Ebola virus disease ... No hemolytic anemia ... , and possibly PCR ... Fever #Travel #Differential
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