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diagnosis hematology algorithm hemolytic causes extravascular intravascular oncology agglutinin classification cold disease gap globulin hepatitis hodgkins injury liver lymphoma management
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Cold AIHA • Alloimmune ... Cold AIHA • PCH ... • PNH ... anemia •
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... hemoglobinuria (PNH ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Membrane): - Autoimmune ... Liver Disease, PNH ... Defects: Sickle cell anemia ... Laboratory Tests
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... , CKD • Hemolytic ... PK, HbC, HbSS, PNH ... - Extrinsic: Autoimmune ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... platelet decrease - PNH ... elliptocytosis, autoimmune ... #Anemia #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... - Mycoplasma, EBV ... younger pts) Differential ... • Diagnostic Test ... #anemia #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... HBV, HCV, HEV, EBV ... : Autoimmune hepatitis ... extrahepatic source - Tests ... diagnosis #algorithm #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic ... anemia due to cold ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Immunosuppression • Autoimmune ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... Cirrhosis, ETOH, autoimmune ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
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