9 results
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Liver Disease, PNH ... Defects: Sickle cell anemia ... Laboratory Tests ... Differential #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Cold AIHA • PCH ... • PNH ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... - Mycoplasma, EBV ... • Diagnostic Test ... Donath-Landsteiner test ... #hematology #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
K), H. pylori test ... thyroid function test ... changes), high MCV anemia ... When do you do a BM ... Causes #Workup #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... stone, Malignancy, PBC ... extrahepatic source - Tests ... diagnosis #algorithm #hepatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic complaints- anemia ... the “Chewing gum test ... in literature (NEJM ... cases (Cornelia NEJM ... them, but urgent rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... (-) hemolytic anemia ... Paraproteinemias #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
acute HIV, HBV, EBV ... lung cancers, HCC ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Diagnostic Tests ... • ANA < 20 % IBM ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology