6 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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Diagnosis Algorithm ... AIHA • PCH ... • PNH ... immune-complex hemolytic anemia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
hemoglobinuria (PNH ... (e.g. primary cold ... #Causes #differential ... #diagnosis #hematology ... #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... the RBCs causing intravascular ... • Diagnostic Test ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... : Warm AIHA, Cold ... Defects: Sickle cell anemia ... Laboratory Tests ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... elliptocytosis, autoimmune ... #workup #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... HBV, HCV, HEV, EBV ... extrahepatic source - Tests ... #hepatology