962 results
Systematic changes affecting anesthesia in the obese patient.

 - Mark Harris, MD MPH @ https://twitter.com/MarkHarrisMD

#Obesity #Anesthesiology
Mark Harris, MD MPH ... Anesthesia #Obese #Pathophysiology
Aortic Regurgitation - Pathophysiology
 • Early Mild Aortic Regurgitation
 • Chronic Severe Aortic Regurgitation
 • Decompensated
Regurgitation - Pathophysiology ... Karan Desai MD, MPH ... Regurgitation #Pathophysiology
Age Related Physiologic Changes and Anesthesia Implications

 - Mark Harris, MD MPH @ https://twitter.com/MarkHarrisMD

#Geriatrics #Aging #Anesthesia
Mark Harris, MD MPH ... Aging #Anesthesia #Pathophysiology
What's in a Blood Gas? VBG vs ABG

BOTTOM LINE: VBG is less painful, more easily obtained
obtained than ABG, pH ... sensitivity & 100% NPV ... Versus #Comparison #PH
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... Nephropathy (low urine pH ... nephropathy (high urine pH ... Syndrome #TLS #Pathophysiology
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
Insulin Pharmacokinetics - Onset and Duration
 • Rapid (aspart, lispro)
 • Short (regular)
 • Intermediate (NPH)
Intermediate (NPH
Lactulose: Mechanism of Action in Hepatic Encephalopathy
Lactulose → ↑ Lactic Acid, Acetic Acid → ↓ pH
Acetic Acid → ↓ pH ... ammonia #hepatology #pathophysiology
Oxygen-Hemoglobin Dissociation Curve

Left Shift (↓ O2 unloading to tissue), Left = Lower:
 • ↓ H+ (↑
Lower: • ↓ H+ (↑ pH ... Dissociation #Curve #pathophysiology
Insulin Comparison Chart - Peak and Duration

Inhaled, Rapid-acting (Analog), Regular, Intermediate-Acting (NPH), Detemir, Glargine, Degludec

- Stephen
Intermediate-Acting (NPH