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diagnosis management neurology als amyotrophic complications diabetes diabeticketoacidosis differential endocrinology gout hematology hyperuricemia k lateral leukostasis lysis myelitis potassium sarcoidosis
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
diffusion of K+ out of cells ... may cause serum ... To prevent hypokalemia ... Signs/Symptoms/Complications ... #pathophysiology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
K+, ACEi/ARBs, NSAIDs ... ↓insulin (DM, DKA ... only if no clear cause ... Drives K+ into cells ... Treatment #potassium #nephrology
Hyperuricemia: Pathogenesis and Complications - Hypercalcemia (due to diseases like Sarcoidosis and Hyperparathyroidism) -> Accumulation of
Complications - Hypercalcemia ... WBCs, and skin cells ... Incr Breakdown of DNA ... Release of purine bases ... Hyperuricemia #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... Lysis of tumor cells ... hydration - Hyperkalemia
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... - Causes progressive ... of UMN and LMN signs ... Escorial criteria uses ... Lateral #Sclerosis #neurology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... tissue: Epithelioid cells ... hyperphosphatemia, hypercalcemia ... symptoms are not caused ... Diagnosis #Management #Signs
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... Pleocytosis > 100 cells ... • Infectious causes ... diagnosis #management #neurology
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