NaCI - GrepMed

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N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in

N-Acetyl Cysteine (NAC ... NAC helps replenish ... Figure 2.1 NAC has ... GSH) precursor, NAC3 ... substitute, and NAC4

Thiazide
diuretics
Carbonic anhydrase
inhibitors
(e.g., acetazolamide)
Nat-Cl symport
Na and HCO;-
reabsorption
Aldosterone
antagonists
(e.g., spironolactone)
Nat channel
(indirect effect)
Loop diuretics (e.g., furosemide)
Amiloride,
#triamterene
Nat-K+-2CF symport
Na channel
(direct effect)
#NaCI reabsorption

direct effect) #NaCI

Gram Positive Cocci - Bacteria Identification Algorithm
Catalase(+)
- Coag(+): Staphylococcus aureus
- Coag(-)

Hemolysis - 6.5% NaCl ... - 6.5% NaCl

#paracetamol #paracetamoloverdose #NAC

paracetamoloverdose #NAC

Adverse Effects of NSAIDs
Prostaglandins decreased
- Gastric mucosal damage with ulcer formation, bleeding, and perforation
-

decreased excretion of NaCl

Addictions: Pathogenesis

Mesolimbic Dopaminergic Pathway:
• Dopaminergic neurons in Ventral Tegmental Area (VTA) in midbrain under continuous

Nucleus Accumbens (NAc ... ) • The NAC receives ... response) • The NAC

Single Syringe Adenosine - Instructions
1) Dilute 6-12 mg of adenosine in a syringe for a total

mL - Use 0.9% NaCl

Fluids, Electrolytes, Acid-Base
)
General Concepts
>
< Osmolality vs osmolarity
★
Osmolality
[H 20)
Milliosmoles per kg of water. The osmolality is the

dissociated salt, like [NaCI

Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-

. ↑ Nacl delivery

Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic

GI Bleed) • NaCl

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