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diagnosis rheumatology sle algorithm erythematosus management anemia clues cns druginduced extravascular glomerulonephritis hemolysis hemolytic intravascular isolated neurology neutropenia progressive rapidly
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... Cerebritis: Labs ... Cerebritis Induction ... CNS #neurology #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... Anticonvulsants • Antibiotics ... Bacteria • Gram Negative ... Destruction • Systemic Lupus ... #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus ... Pauci-immune mediated (Negative ... Glomerulonephritis #Vasculitis #differential
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... pANCA anti-MPO - Negative ... #sle #comparison ... #table #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... Drugs (Beta lactam antibiotics ... #differential # ... diagnosis #hematology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... the face (many differential ... pericarditis » is...lupus ... responsive to antibiotics ... erythematosus #rheumatology
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