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diagnosis anemia autoimmune hemolysis antibody antiglobulin bacilliformis bartonella causes classification cold dat direct disease extravascular fever hodgkins intravascular lymphoma monoclonal
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Differential Diagnosis ... hemoglobinuria) • Cold Agglutinin ... (7-8%) DAT-negative ... #Table #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
- Autoimmune (AIHA ... . primary cold agglutin ... Drugs (Beta lactam antibiotics ... Extravascular #Causes #differential ... #diagnosis #hematology
Expected DAT Results in Autoimmune Hemolysis DAT Negative Hemolysis • DAT Poly ( - ), IgG (
in Autoimmune Hemolysis ... DAT Negative Hemolysis ... ), C3d ( - ) WAIHA ... ( +/- ) Cold agglutinin ... #hematology #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... for anti-C3d and negative ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
1) DIAGNOSE AIHA ... • Blood smear: Differential ... screening 3) TREAT AIHA ... Anemia #diagnosis #management ... #treatment #rheumatology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... bacilliformis: - Gram negative ... lysis → severe hemolytic ... Supportive and antibiotics ... Fever #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Coagulopathy) SMZL: • AIHA ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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