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differential infective management cardiology infectiousdiseases abscess algorithm bcnie betadglucan biomarkers bloodculture bloodcultures chagas children disease fungal galactomannan hepatology liver marantic
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures - Did they receive antibiotics prior
with Infective Endocarditis ... therapy - Number one cause ... Eg: C. burnetii ... Fungal (Histoplasma/Aspergillus ... #Diagnosis #Management
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
is required for diagnosis ... Clinical features: Fever ... Clinical features: Fever ... in up to 30% of cases ... #comparison #infective
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... night sweats, fever ... ↑ ESR, CRP • EKG ... Treat underlying cause
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Coccidioides - Negative ... Cryptococcus - Negative ... post-2010 almost never ... Galactomannan #diagnosis ... #comparison
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... but important causes ... whipplei, Fungi (Aspergillus ... BCNIE Diagnostic ... special stains (e.g
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
aureus, Coagulase-negative ... Tropheryma Whipplei • Aspergillus ... night sweats, fever ... ↑ ESR, CRP • EKG ... Persistent bacteremia/fevers
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... infectious disease caused ... mild (malaise, fever ... serology, smear negative ... 90-120 days • Pediatric
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Common bacterial causes ... • Enteric gram negative ... ., endocarditis) ... liver #abscess #pediatrics ... #differential #diagnosis
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