11 results
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... therapy - Number one cause ... Eg: C. burnetii ... #Infective #Endocarditis ... #Diagnosis #Management
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
specific to NBTE, and diagnosis ... is required for diagnosis ... Frequent false-negative ... in up to 30% of cases ... #comparison #infective
A toxidrome is a syndrome (set of symptoms) caused by specific medications or toxins.

There are 5
set of symptoms) caused ... methylphenidate (Ritalin) - Sedative-Hypnotic ... antihistamines #Diagnosis ... #Toxicology #Toxidromes ... #Comparison #Table
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
• Coagulase-negative ... Septic Emboli Cause ... Diagnosis? ... ↑ ESR, CRP • EKG ... Treat underlying cause
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Infective Endocarditis ... but important causes ... BCNIE Diagnostic ... special stains (e.g ... #Infective #Endocarditis
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... greater effect on negative ... distribution (1.6 – 7 L/kg ... Clozapine is known to cause ... #Toxicity #Diagnosis
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
Common bacterial causes ... • Enteric gram negative ... ., endocarditis) ... liver #abscess #pediatrics ... #differential #diagnosis
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential Diagnosis ... aureus, Coagulase-negative ... staphylococci Culture Negative ... Septic emboli cause ... ↑ ESR, CRP • EKG
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary
Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... infectious disease caused ... serology, smear negative ... 90-120 days • Pediatric ... Trypanosomiasis #Diagnosis
Hyperthermic Toxidromes
Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures.
 • Sympathomimetic -
dopamine blockers (e.g ... pharmacogenetic disease caused ... Hyperthermic #Toxidromes #comparison ... #table #diagnosis ... #differential #toxicology