18 results
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... Myelofibrosis Stem cell ... Toxins • Aplastic Anemia ... #Differential # ... Algorithm #Causes #Hematology
Approach to the Rash in a an oncology patient - MINT-C Mnemonic
M - Malignancy: Leukemia cutis,
ie petechiae), Neutropenia-specific ... dermatoses #skin ... #differential # ... diagnosis #cancer ... MINTC #Mnemonic #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... or functional neutropenia ... lymphoid organs When Cancer ... -> Invade Skin: ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Hepatomegaly • Skin ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... workup #oncology #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Index < 2: • Anemia ... infiltration (e.g. cancer ... defects (e.g. sickle cell ... Production #Index #hematology ... #anemia #differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Maculopapular rash ... reticularis Differential ... syndrome • Giant cell ... #rash #diagnosis ... #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... for anti-C3d and negative ... malignancies -> CLL ... younger pts) Differential ... #hematology #diagnosis
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential ... Megaloblastic anemia-rare ... including white blood cell ... #differential # ... diagnosis #causes #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... Neutrophil (Normal) Differential ... likelihood of negative ... #differential # ... neutrophil #WBC #CBC #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... • Cervical cancer