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differential workup leukemia management chronic cll hemolytic lymphocytic monoclonal rheumatology testing agglutinin aiha arthritis autoimmune bandemia cbc cell classification cold
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... Table Warm AIHA ... Cold Agglutinin Disease ... AIHA (7-8%) DAT-negative ... #Table #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
ULN R - Renal disease ... 40 ml/min A - Anemia ... Causes of false- negative ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... , Drugs, Liver Disease ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory ... #hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Commonly Observed Laboratory ... chronic liver disease ... deficiency - Anemia ... LiverFailure #Hepatic #Hepatology ... #Laboratory #Diagnosis
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... hallmark for the disease ... result in severe anemia ... antiglobulin tests - Negative ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... for anti-C3d and negative ... #hemolytic #anemia ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... • Autoimmune diseases ... likelihood of negative ... #differential #diagnosis ... neutrophil #WBC #CBC #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
pANCA anti-MPO - Negative ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
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