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diagnosis hematology thrombocytopenia algorithm cardiology causes hemolytic workup agglutinin arthritis bandemia canimorsus capnocytophaga cbc clinical cold disease disorders erythematosus framework
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... • Bacterial endocarditis ... #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... Vasculitis • Infection ... Algorithm #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Thrombocytopenia - Differential ... infiltration: malignancy, infection ... - Autoimmune: SLE ... valve replacement, endocarditis ... Diagnosis #Framework #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... overlook severe infections ... likelihood of negative ... #differential # ... neutrophil #WBC #CBC #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... genotypes): SS, SC, SE ... inclusions - If infection ... Algorithm #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... for anti-C3d and negative ... younger pts) Differential ... #hematology #diagnosis
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... • Bacterial endocarditis ... aureus • Gram-negative ... arthritis • SLE ... Symmetrical: • RA • SLE
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Bandemia, AKI. ... fastidious gram-negative ... to meningitis, endocarditis ... Canimorsus #Skin #Rash #dermatology ... #clinical #photo
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Infectious: • Pre-existing ... • Autoimmune (SLE ... • Coagulase-negative ... Marantic (NTBE) Differential ... Leukocytosis, anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... procedures - Infection ... test, ANA (e.g., SLE ... changes), high MCV anemia ... Causes #Workup #hematology
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