25 results
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Aplastic Anemia ... Definition • Pathophysiology ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic Anemia ... (AIHA) Pathophysiology ... C3 positive or negative ... #Pathophysiology ... #diagnosis #hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... - Differential Diagnosis ... Table Warm AIHA ... AIHA (7-8%) DAT-negative ... #Table #hematology
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... #bradycardia #Causes ... #differential #diagnosis ... #infectiousdiseases ... #table #NonInfectious
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... old, ~10,000 new cases ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... Causes of false- ... negative SPEP: ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Pauci-immune mediated (Negative ... #differential #diagnosis ... #algorithm #rheumatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Differential Diagnosis ... likelihood of negative ... #differential #diagnosis ... neutrophil #WBC #CBC #hematology ... #pathophysiology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... result in severe anemia ... antiglobulin tests - Negative ... immune hemolytic anemia ... #Workup #Hematology