65 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... infective endocarditis ... #Endocarditis # ... InfectiousDiseases
HACEK is the acronym commonly used to describe and help doctors to remember a group of
fastidious Gram-negative ... which can also cause ... is caused by HACEK ... is caused by Alpha-haemolytic ... #Diagnosis #InfectiousDiseases
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... Blood Cultures ... therapy - Number one cause ... #Infective #Endocarditis ... #Diagnosis #Management
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
from Infective Endocarditis ... serology: Serial negative ... Frequent false-negative ... cultures/serology: + (Negative ... in up to 30% of cases
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... diagnosis #algorithm #rheumatology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... but important causes ... #Infective #Endocarditis ... differential #workup #infectiousdiseases
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Microbiology: Blood ... • Coagulase-negative ... Septic Emboli Cause ... • Blood cultures ... #diagnosis #management
Childhood Immunization Schedule: Why we immunize
 • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
invade URT & via hematologic ... CNS and hematologic ... disseminates in blood ... fetal blood vessel ... peds #pediatrics #pathophysiology
Bacteremia Quick Reference - Treatment Duration

Gram Negative Bacteremia:
 • Avoid: Aminoglycosides and tigecycline
 • Catheters should
Duration Gram Negative ... - Follow-up blood ... therapy (if repeated blood ... Bacteremia #Treatment #Management ... #Duration #infectiousdiseases
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... Physiologic Causes ... Pathologic Causes ... • Infective Endocarditis ... Differential #Diagnosis #Pathophysiology