25 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... infective endocarditis ... #Endocarditis # ... InfectiousDiseases
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... Blood Cultures ... therapy - Number one cause ... #Infective #Endocarditis ... #Diagnosis #Management
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
DIAGNOSE AIHA • Anemia ... type ± C3d • Blood ... 2) LOOK FOR a cause ... #diagnosis #management ... #treatment #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Cryoglobulinemia, Endocarditis ... Pauci-immune mediated (Negative ... diagnosis #algorithm #rheumatology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Microbiology: Blood ... • Coagulase-negative ... • Blood cultures ... Leukocytosis, anemia ... #diagnosis #management
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... Physiologic Causes ... iron deficiency anemia ... • Infective Endocarditis ... Differential #Diagnosis #Pathophysiology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... but important causes ... #Infective #Endocarditis ... differential #workup #infectiousdiseases
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
of peripheral blood ... cultures, including blood ... likelihood of negative ... neutrophil #WBC #CBC #hematology ... #pathophysiology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... of Peripheral blood ... antiglobulin tests - Negative ... immune hemolytic anemia ... Diagnosis #Workup #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... and petechiae Causes ... result from low blood ... #oncology #hematology ... #diagnosis #management