77 results
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... in macrophages Diagnosis ... in GBA1 gene Clinical ... #Diagnosis #Signs
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
pathognomonic signs ... high index of clinical ... is required for diagnosis ... : Serial negative ... - Infectious Diseases
Relative Afferent Pupillary Defect

This maneuver of intermittent light stimulus is called the alternating light test or
Relative Afferent ... It is a clear sign ... very sensitive diagnostic ... Pupillary #Defect #Neurology ... #Clinical #Video
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... Pathogenesis and Clinical ... the etiology Signs ... GravesDisease #pathophysiology ... #diagnosis
Asterixis is a type of negative myoclonus characterized by irregular lapses of posture of various body
Asterixis is a type of negative ... associated with liver disease ... #PhysicalExam #clinical ... #diagnosis #video
Woltman’s sign on Physical Exam

53-year-old man presented with fatigue and sensitivity to cold. A physical examination
Woltman’s sign on ... evaluation confirmed a diagnosis ... deep-tendon reflex, is a neurologic ... Reflexes #Delayed #Clinical ... #Video #Neurology
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
inflammatory cells) Clinical ... : • Disease fatal ... exertion • Neurologic ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Pathogenesis and Clinical ... intervertebral disc disease ... Stabbing) - Negative ... MeralgiaParesthetica #MSK #pathophysiology ... #signs #symptoms
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski)

Brudzinski's sign is characterized
While the pathophysiology ... despite severe disease ... Video by Dr. ... #Meningitis #Clinical ... #Video #PhysicalExam
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Pathogenesis and Clinical ... Findings • Negative ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis