29 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Differential Diaqnoses ... Coxsackie, CMV, EBV ... • Ocular: uveitis ... management #treatment #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
to Kidney: Anti-GBM ... involvement: Anti-GBM ... Pauci-immune mediated (Negative ... #differential #diagnosis ... #algorithm #rheumatology
Point-of-care Ultrasound for Diagnosis of Abscess in Skin and Soft Tissue Infections

1. POCUS is more accurate
Ultrasound for Diagnosis ... POCUS is more accurate ... POCUS has a negative ... LikelihoodRatios #Accuracy #Diagnosis ... VisualAbstract #EBM
Rheumatoid Arthritis - 2020 ACR-EULAR Classification
≥ 6 of 10 points = definite RA
Joint Involvement:
Arthritis - 2020 ACR-EULAR ... at least 1): Negative ... RF, negative anti ... Rheumatoid #Arthritis #diagnosis ... #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... A nonpruritic macular ... dysfunction, and negative ... #Adult #onset #Stills ... #rheumatology #
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM ... Her ocular exam ... pack test were negative ... PhysicalExam #clinical #video
Oroya Fever
Hematologic disease caused by Bartonella bacilliformis
Restricted to the Andes highlands of Peru & Ecuador
B. bacilliformis:
bacilliformis: - Gram negative ... fever, malaise, chills ... : ​• Miliar → Nodular ... → Mular DIAGNOSIS ... #Oroya #Fever #diagnosis
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
pulmonary emboli, and ocular ... Cryofibrinogenemia Diagnosis ... levels >1g/L • Negative ... cryoglobulins • Negative ... #rheumatology #
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... +, Adult-onset Still ... biologics (CMV +++, EBV ... Lymphohistiocytosis #diagnosis ... treatment #summary #rheumatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
for anti-C3d and negative ... - Mycoplasma, EBV ... : High fevers, chills ... hemolytic #anemia #hematology ... #diagnosis