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diagnosis algorithm hepatitis obstetrics pregnancy biliary cholangitis cirrhosis common comparison cvid dermatology disease elevatedmcv fatty gap globulin hellp hypogammaglobulinemia icp
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... (DIC, ascites, jaundice ... infiltration) Differential ... Pregnancy #hepatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Myelodysplastic Syndromes ... #elevatedMCV #Differential ... #Hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Pruritus, Mild jaundice ... necrosis HELLP Syndrome ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
: Alcohol use, Liver ... Myelodysplastic syndrome ... morphologic #mcv #differential ... #diagnosis #causes ... #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... - Hemolytic anemia ... Kasabach-Merritt syndrome ... deficiency • Liver ... #Diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... hyperpigmentation • Jaundice ... obstruction • ALP ... bile ducts Differential ... diagnosis #workup #hepatology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential ... Diagnosis Neonate ... Chediak-Higashi syndrome ... Megaloblastic anemia-rare ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Sarcoidosis) • Liver ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
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