23 results
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... discomfort Signs: Jaundice ... Elevated ALP 2. ... Diagnosis #Algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... (ALT or AST > ALP ... Wilsons, Pregnancy - AFLP ... Congenital, Others, Cirrhosis ... Algorithm #diagnosis #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... hyperpigmentation • Jaundice ... obstruction • ALP ... bile ducts Differential ... diagnosis #workup #hepatology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... Cholangiocarcinoma • Primary ... Cholangitis #Jaundice ... #Differential # ... Algorithm #Causes #Hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... (DIC, ascites, jaundice ... infiltration) Differential ... iMedEducation #AFLP ... Liver #Pregnancy #hepatology
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Etiologies of Cirrhosis ... congenital - Primary ... biliary cirrhosis ... #Diagnosis #Differential ... #Hepatology #Cirrhosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... • Pregnancy - AFLP ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... #LiverEnzymes #Differential
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hepatomegaly - Differential ... Malignant • Primary ... Biliary Cirrhosis ... #Hepatomegaly #Differential ... Algorithm #Causes #Hepatology
Primary sclerosing cholangitis (PSC) - Malignancy Screening and Surveillance Recommendations 

Cholangiocarcinoma 
 - Annual US or
Primary sclerosing ... lesions HCC (with cirrhosis ... q 6 months +/- AFP ... GregoryTBrennan #Primary ... Gastroenterology #Management
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
) Elevation - Differential ... - Increased ALP ... - Drugs - Primary ... #Elevation #Differential ... Diagnosis #Algorithm #hepatology