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diagnosis rheumatology syndrome sle summary erythematosus hemophagocytic hlh leukemia lymphohistiocytosis systemic table activation behcet cerebritis chronic classification cll coagulation coccidioides
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... autoantibodies that will cause ... cerebritis #diagnosis #management ... #treatment
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Scleromyxedema (CNS ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • 8%-27% for CNS ... DI Hematologic ... Adenocarcinoma Treatment ... #Diagnosis #Management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Positive in 60-80% of cases ... life-threatening • Treatment ... Evolution: Chronic disease ... #Summary #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
(90-95% of cases ... number of sites of disease ... Treatment • Early ... classification #hematology ... #oncology #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... Usual therapeutic management ... Evolution: Chronic disease ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
, B-cell lymphoma ... Treatment: • ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... Ischemia, Leukemia, Lymphoma ... Arthritis, AS Treatment ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
to large cell lymphoma ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... involvement • 30%: CNS ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
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