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nephrology diagnosis differential algorithm hyponatremia pathophysiology table causes diuretics excretion gitelman hypokalemia hypotonic mechanisms medications pharmacology physiologic renal treatment workup
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
• Euvolemic (Low ... • Hypovolemic: Diuretics ... , Cushing syndrome ... Workup #Algorithm #nephrology ... #sodium
Mechanisms of nephron damage in cardiorenal syndrome • Increased renal interstitial pressure • Hypoperfusion • Reduced
syndrome • Increased ... Reduced renal blood flow ... hypertrophy • Sodium ... activities • Diuretic ... pathophysiology #nephrology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
: SIADH, Renal Sodium ... can be high or low ... Cirrhosis, Nephrotic syndrome ... Primary polydipsia), Low ... #nephrology
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
Cirrhosis, Nephrotic syndrome ... , Medications (diuretics ... Primary polydipsia, Low ... Algorithm #diagnosis #sodium ... #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
irrigation • Management ... • Hyponatremia ... • Nephrogenic ... and euvolemic hyponatremia ... #Nephrology #Pharmacology
Hypernatremia - Differential Diagnosis and Treatment Hypernatremia is almost always due to unreplaced water loss (free water
, Dehydration: neurologic ... unavailable 2) Osmotic Diuresis ... Diabetes Insipidus: neurogenic ... Diagnosis #Treatment #management ... #nephrology #sodium
Hyponatremia - Differential Algorithm Isotonic Hyponatremia: Hyperlipidemia, Hyperproteinemia, Recent TURP Hypotonic Hyponatremia: • Hypovolemia: Diuretics/Nephropathies, Vomiting, Diarrhea,
Hyponatremia - Differential ... • Hypovolemia: Diuretics ... Cirrhosis, Nephrotic Syndrome ... diagnosis #causes #nephrology ... #sodium #low
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
thiazide-sensitive sodium ... thiazide-sensitive sodium ... with thiazide diuretic ... alkalosis • Normal or low ... #management #pathophysiology
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