12 results
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
Renal losses, Cerebral ... uric acid <4 • SIADH ... deficiency, Primary polydipsia ... algorithm #diagnosis #sodium ... #low #nephrology
Cerebral Salt Wasting vs SIADH - Pathophysiology 
1) Neurological event
2) Sodium loss from tubules
3) Naturiesis →
Cerebral Salt Wasting ... vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... → Subclinical volume ... #hyponatremia #
Hypernatremia Diagnosis and Workup

Step 1 . Repeat the sodium concentration.
Step 2.  Check plasma osmolality.
NORMAL PLASMA
Hypernatremia Diagnosis ... Repeat the sodium ... EUVOLEMIC • SIADH ... • psychogenic polydipsia ... Workup #Algorithm #Nephrology
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
OFF (UNa > 30): SIADH ... Reset osmostat, Cerebral ... 100): Primary polydipsia ... Algorithm #diagnosis #sodium ... #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
poor response to volume ... , Renal Sodium loss ... Insufficiency, Cerebral ... intake (Primary polydipsia ... #nephrology
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
Hyponatremia - Differential ... ADH secretion (SIADH ... osmostat - Cerebral ... failure - Primary polydipsia ... Table #Causes #Sodium
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
Hyponatremia - Differential ... Hypovolemic - Give volume ... - Primary Polydipsia ... , SSRIs) - SIADH ... #sodium
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
, Dehydration: neurologic ... Diabetes Insipidus: neurogenic ... patients at risk for cerebral ... Diagnosis #Treatment #management ... #nephrology #sodium
Management of SIADH
Treat underlying cause:
 • Causes can include pain, primary lung pathology, post-operative phenomenon, medications,
Management of SIADH ... administered • Can cause volume ... promoting passive sodium ... #Management #hyponatremia ... #nephrology #treatment
Primary Polydipsia
Definition: Excessive volitional water intake
Epidemiology:
 • 6-20% of patients with psychiatric disorders - Most commonly
• Symptomatic hyponatremia ... Pseudohyponatremia, SIADH ... , Urine Sodium ... #diagnosis #management ... #nephrology