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Mechanisms of Pain Mixed - Nociceptive/Neuropathic Nociceptive - Tissue Damage - Visceral - (From organ/cavity lining) Poorly localized,
Mechanisms of Pain ... - Nociceptive/Neuropathic ... Complex regional pain ... Spinal injury #Pain ... Diagnosis #Algorithm #Causes
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Bone/Joint Causes ... Hematoma Venous Causes ... Edema Arterial Causes ... • Neuropathy (DM ... syndrome, peroneal neuropathy
Causes of Constipation - Differential Diagnosis Framework • Motility: Diet, IBS-C, Colonic inertia, Pelvic floor disorders,
Causes of Constipation ... Spinal cord injury, Neuropathy ... disease, Anal pain ... Differential #Diagnosis #Causes
Lyrica (Pregabalin) Indications: Neuropathy (diabetic, postherpetic neuralgia, fibromyalgia, & spinal cord injury), Adjunctive therapy for partial-onset
Indications: Neuropathy ... and for nerve pain ... fibromyalgia, PHN, & pain ... drug will likely cause ... #Pharmacology #Neuropathy
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... sensation, etc) • Neuropathic ... pain (shooting, ... lancinating, burning pain ... • Pain/sensory disturbance
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... risk of joint pain ... impairment • Neuropathy ... Elevated Vit B6- neuropathy ... Phosphatase: • Other causes
Lower Extremity Dermatomes and Myotomes Reflexes: • Knee - L2, L3, L4 • Ankle - S1
Syndrome - Low back pain ... Emergency • Peroneal Neuropathy ... Commonly caused
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... cognitive slowing, neuropathy ... GI - glossitis (pain ... of tongue), abd pain ... LN, peripheral neuropathy
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... weakness - Nerves: neuropathy ... tract: abdominal pain ... gut -> abdominal pain ... , testes -> pain
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations Causes of Thiamine Deficiency: • Poor intake: - Diets
Manifestations Causes ... Symmetrical peripheral neuropathy ... reflexes - Burning pain ... to peripheral neuropathy
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