17 results
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... frequently affects infants ... • Bicytopenia Treatment ... #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... Drugs, Unknown cause ... Treatment: • ... #diagnosis #management ... #rheumatology
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
Diagnosis and Management ... donovani, Leishmania infantum ... Weight Loss • Can cause ... Hemophagocytic Lymphohistiocytosis ... culture, PCR, K39) Treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... #Summary #rheumatology
Mains Electricity Failure - Guidelines for Crises in Anaesthesia
Unexpected total power failure is rare and unpredictable.
Guidelines for Crises ... oxygen supply intact ... Anesthesiology #Anesthesia #Intraoperative ... Checklist #Diagnosis #Management ... #Workup
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
Intraoperative Anaphylaxis ... trolley, anaphylaxis treatment ... require prolonged treatment ... Checklist #Diagnosis #Management ... #Workup
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
Treatment depends ... maintained fever CAUSES ... devices, especially infants ... Checklist #Diagnosis #Management ... #Workup
Cardiac Tamponade - Guidelines for Crises in Anaesthesia
Caused by an accumulation of blood, pus, effusion fluid
thoracotomy is a better treatment ... Plan definitive management ... Anesthesiology #Anesthesia #Intraoperative ... Checklist #Diagnosis #Management ... #Workup
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... • Immunologic Workup ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... (HLH) Treatment ... Hemophagocytic #Lymphohistiocytosis ... #HLH #Treatment ... #management #hematology