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pharmacology hereditaryspherocytosis management medications nejm nsaids spherocytosis table acyclovir anesthesia antihypertensive betablockers brevibloc cardiology cardioselective cirrhosis clinical comparison coxinhibitor cyclooxygenase
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
NSAID Selectivity ... increased CV risk Nonselective ... effects Irreversible Nonselective ... effects #NSAIDs #selectivity
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 Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa - Interaction
- LMWH selectively
Beta Blockers Overview - Beta Adrenergic Antagonists Cardioselective: M - Metoprolol A - Atenolol N - Nebivolol B
Cardioselective #NonSelective
Acyclovir - Pharmacology Summary • Mechanism of Action: Nucleoside analog - selectively inhibits viral replication of
Nucleoside analog - selectively
Antihypertensive Drugs - Summary Diuretics: • Thiazide type: Chlorothiazide, Hydrochlorothiazide • Thiazide-like: Chlorthalidone, Indapamide, Metolazone • Loop
Many others • Nonselective
NSAIDS and COX Selectivity Relative selectivity of some commonly used NSAIDs. Data shown as the logarithm of
NSAIDS and COX Selectivity ... Relative selectivity ... COX-1 Selectivity ... Fenoprofen COX-1 Selectivity ... #pharmacology #selectivity
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
ratio and are selectively
Sedative-Hypnotic Drugs Benzodiazepines: - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
Hyponotics: - Bind selectively
Preventing Decompensation in Cirrhosis cACLD, CSPH, and the Rule of Five Prevention of Decompensation Nonselective Beta Blockers (NSBB) Preventing
Decompensation Nonselective
Peripheral-Blood Smear. A peripheral-blood smear (Wright’s stain) shows spherocytes (selectively indicated by arrows). #Clinical #Pathology #Spherocytosis
shows spherocytes (selectively
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