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diagnosis hepatology differential ascites biliary causes cell cirrhosis creactiveprotein crp endocrinology erythematosus fever function fuo hscrp hyperthyroidism inflammation laboratory lfts
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
disease • Acute liver ... failure • Primary ... biliary cholangitis ... cholangitis • ... #Hepatology #causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
wasting PBC Labs ... • ALT & AST normal ... • Bilirubin - Normal ... #diagnosis #workup ... #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
(LFTs) - Normal ... Values and Interpretation ... prothrombin time across labs ... #Interpretation ... #diagnosis #hepatology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
FUO) - Further Workup ... Returning Traveler’ algorithm ... artery biopsy • Lab ... values supporting ... hematologic malignancies
Approach to Thyroid Function Tests in the Evaluation of Hyperthyroidism • Low TSH, Low normal T4
Hyperthyroidism: Work-up ... Can repeat labs ... high T4 +/- T3 → Primary ... Hyperthyroidism #algorithm ... endocrinology #TFTs #TSH #Interpretation
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
the context of primary ... pneumonitis • Diffuse ... enteropathy, and diffuse ... Cytopenias • Cardiac valve ... flares • CRP normal
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... that a one-off value ... Better call hematology ... exogenous, EPO levels: normal ... #workup #hematology
C-REACTIVE PROTEIN Discovered by Tillett & Francis in 1930. First identified as a substance in the serum
synthesized by the liver ... protein that is primarily ... Lab values vary, ... Interpretation of ... than 0.3 mg/L: Normal
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
-70 y/o • 2/3 Males ... common - GI tract, liver ... except for the primary ... Oncology #Diagnosis #Workup ... #Hematology
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