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oncology blood myelodysplastic product reactions workup activation apml cell chronic cll cvid differential differentiation erythematosus essential et gap globulin hepatopulmonary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
(MD) - Diagnosis ... cytopenias (usually anemia ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anemia: - Hepatitis ... (MDS) (normal or ... anemia) Labs ... anemia Treatment ... #hematology #diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... : • Labs: leukocytosis ... 500 mg QD until normal ... #management #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... levels are within normal ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... Most common cytopenia ... • Aplastic Anemia ... factor (GCSF) treatments ... #diagnosis #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• HLH Labs: ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Noninfectious hepatitis ... Cytopenias • Cardiac valve ... lymphopenia, low PLT • Anemia ... Kidney disease common ... #Rheumatology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... • Dyspnea - Common ... - Lizzie Aby, MD ... #diagnosis #management ... #treatment #hepatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Epidemiology: • Most common ... CLL Labs: 1. ... • Neutropenia, anemia ... Pure red cell aplasia ... workup #oncology #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... Nephrogenic DI Hematologic ... #Rheumatology # ... Diagnosis #Management
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