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mds myelodysplastic rheumatology workup activation apml cell chronic cll common cvid differential differentiation hypogammaglobulinemia immunodeficiency immunology injury leukemia lymphocytic macrophage
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
marrow) -dys- (abnormal ... ) -plastic (shape ... cytopenias (usually anemia ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Anemia: - Hepatitis ... anemia) Labs ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... vein: Budd-chiari syndrome ... - If both are normal ... #algorithm #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... : • Labs: leukocytosis ... 500 mg QD until normal ... #management #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
CLL Labs: 1. ... • Neutropenia, anemia ... Pure red cell aplasia ... #workup #oncology ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... levels are within normal ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... vasculitis: 10%-16% Liver ... • Autoimmune hepatitis ... Nephrogenic DI Hematologic ... Diagnosis #Management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• HLH Labs: ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
common - GI tract, liver ... • No CRAB - no anemia ... Bone marrow Treatment ... #Plasmacytoma #Oncology ... #Hematology
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