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diagnosis differential management causes injury ascites elevated rheumatology saag transaminitis aclf aflp aih albumin alcoholic aplastic autoimmune chemistry chronic cirrhosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
disease, liver ... Alcohol-Associated Hepatitis ... Injury (DILI) ... Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis ... #algorithm #hepatology
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... hepatomegaly and anemia ... Hepatobiliary #hepatology ... #hepatitis #differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... viral hepatitis ... viral hepatitis ... Chronic viral hepatitis ... #differential #Hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Causes of Ascites Normal ... Liver disease ... - Alcoholic hepatitis ... fibrosis - Acute ... #differential #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... Clues to non-cirrhotic ... • Cirrhosis/acute ... hepatitis • Infiltrative ... Diagnosis #causes #hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... hepatitis • Ischemic ... hepatitis • Acute ... distinguishes ischemic hepatitis ... 1.5) from viral hepatitis
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