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diagnosis differential causes injury saag albumin alcoholic chemistry druginduced erythematosus gap globulin gradient hiv hypertension interpretation lfts lupus management portal
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ... dechallenge • Acute ... ), Chronic hepatitis ... • Autoimmune hepatitis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Normal Peritoneum ... Liver disease ... - Alcoholic hepatitis ... fibrosis - Acute ... #differential #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... viral hepatitis ... viral hepatitis ... Chronic viral hepatitis ... #differential #Hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
HTN: ascites (SAAG ... Ascites protein ... • Cirrhosis/acute ... hepatitis • Infiltrative ... Diagnosis #causes #hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
- Alcoholic hepatitis ... - Massive liver ... ) - Portal vein ... - Acute fatty ... Differential #Diagnosis #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... blood, urine and ascites ... HCV, DILI, HCC, ... #Alcoholic #Hepatitis ... #hepatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... Noninfectious hepatitis ... Cytopenias • Cardiac valve ... lymphopenia, low PLT • Anemia ... , Serositis Labs
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Syndrome Acute ... manifestations Labs ... enzymes ↑ • Mild anemia ... infection • Viral hepatitis ... ART to slow HIV disease
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
HBV, EBV, VZV, hepatitis ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
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