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diagnosis differential management injury rheumatology transaminitis alcoholic aplastic ascites chemistry common cvid druginduced elevated erythematosus gap globulin hiv hypertension hypogammaglobulinemia
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... disease, Hepatic ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... Transaminases #hepatitis ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... #injury #hepatitis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... • Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... #Acute #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... viral hepatitis ... viral hepatitis ... Chronic viral hepatitis ... #differential #Hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
and hepatorenal syndrome ... Clues to non-cirrhotic ... • Cirrhosis/acute ... hepatitis • Infiltrative ... #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Normal Peritoneum ... Liver disease ... - Alcoholic hepatitis ... fibrosis - Acute ... #differential #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... HCV, DILI, HCC, ... #Alcoholic #Hepatitis ... #hepatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... : - Hepatitis ... ) Labs: • Peripheral ... Treatment: ... #oncology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
HBV, EBV, VZV, hepatitis ... ETOH, autoimmune hepatitis ... PBC, PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
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