9 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Triggers: ATRA treatment ... Diagnosis: • Labs ... 500 mg QD until normal
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- ACS, AKI, acute ... values: WBC >100k ... , + lab signs of ... values: Elevated ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Classification: • Acute ... Pleural effusions • Acute ... Cytopenias • Cardiac valve ... flares • CRP normal
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
important to recognize Acute ... importantly, bedside ultrasound ... is vital while lab ... coronary syndrome ... icu #clinical #pharmacology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
CLL Labs: 1. ... microglobulin Treatment ... • Richter’s Syndrome ... Transform to DLBCL, PML ... ’s lymphoma or acute
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Ocular examination Labs ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... : • Severe oral ... #Rheumatology #
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... (Acute Febrile ... Excellent response to treatment ... Abnormal laboratory ... values at presentation
Gout - Diagnosis and Management Summary

3 Conditions for Gout to Manifest:
1. Hyperuricemia
2. Monosodium urate deposition in
sex • Metabolic syndrome ... not possible • Ultrasound ... cortical bone Treatment ... gout treatment; ... #rheumatology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
presents with acute ... pulmonary symptoms • Rheumatologic ... Diagnosis: • Labs ... and Ohio River valleys ... level • A low or normal