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differential oncology management aplastic apml cancer cll common cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology leukemia lupus lymphocytic myelodysplasia myelodysplastic
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... , deficiency anemia ... : Chronic infections ... and viral infections ... #Algorithm #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Syndrome Acute ... Syndrome Symptoms ... Fever (75%) • Encephalopathy ... enzymes ↑ • Mild anemia ... -1/HIV-2 differentiation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... - Hemolytic anemia ... - APLS • Acute ... #hematology #rheumatology ... #nonpalpable #dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
(MDS) (normal or ... Treatment: ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... impaired B-cell differentiation ... levels are within normal ... syndrome, HIV) ... hypogammaglobulinemia #immunology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation ... : >3 symptoms, or ... : Infection (sepsis ... 500 mg QD until normal ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... age 70 years Symptoms ... Marrow Failure • Chronic ... blood cells appear normal ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... with Lupus: • Chronic ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... infections (acute ... HIV, HBV, EBV, ... gastric tumors • Hematology ... #hematology
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