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differential oncology management apml cll cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology leukemia lupus lymphocytic myelodysplasia myelodysplastic platelets protein proteingap
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... , deficiency anemia ... : Chronic infections ... and viral infections ... #Algorithm #hematology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Syndrome Acute ... Syndrome Symptoms ... Most common: Oral ... enzymes ↑ • Mild anemia ... -1/HIV-2 differentiation
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation ... : >3 symptoms, or ... : Infection (sepsis ... 500 mg QD until normal ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... impaired B-cell differentiation ... levels are within normal ... syndrome, HIV) ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... age 70 years Symptoms ... Most common cytopenia ... Marrow Failure • Chronic ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... Physical Exam/Signs ... • Neutropenia, anemia ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... Induced Lupus: • Symptoms ... Kidney disease common ... with Lupus: • Chronic ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
infections (acute ... HIV, HBV, EBV, ... gastric tumors • Hematology ... Comment on type ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Nodosa: • PAN most commonly ... • Progressive symptoms ... Eosinophilia, asthma, chronic ... #Rheumatology
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