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differential hepatology causes abnormal appearance lesions prolonged pt radiology table aflp arterial bleeding bruising chemistry computedtomography contrast dermatology dic disease
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
DIC • Severe Liver ... INR < 2.3 - APTT ... < 1.5 x normal ... #diagnosis #causes ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #Causes #diagnosis ... #differential #hematology
Appearance of Liver Lesions on Various Imaging Modalities • Computed Tomography (CT) - Arterial Phase, Portal
Appearance of Liver ... Computed Tomography (CT ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Appearance of Liver ... Arterial Phase, Portal ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... #Causes #diagnosis ... #differential #hematology ... #coagulation
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
imaging: Normal ... • Histology: Normal-mild ... necrosis HELLP Syndrome ... obstetrics #hepatitis #comparison ... #differential #diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... Acquired: • Heparin ... von Willebrand syndrome ... PT/NORMAL PTT: ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Kasabach-Merritt syndrome ... deficiency • Liver ... Gardner-Diamond syndrome ... #Differential #Diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- If both are normal ... • Albumin • Coagulation ... replaced by non-hepatic ... • Gilbert's syndrome ... #chemistry #diagnosis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... , Ischemic Liver ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... pathophysiology #hematology
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