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differential causes abnormal aptt prolonged algorithm disseminated intravascular laboratory bruising chemistry disorders hemostasis hodgkins inr interpretation isth lfts liver lymphoma
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PT (INR) - Bleeding ... PT (INR) - No Bleeding ... #Differential #Diagnosis ... Algorithm #Causes #Hematology ... #coagulation #disorders
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Coagulation Tests ... - Prolonged PT ... and Prolonged PT ... #Laboratory #Hematology ... #Diagnosis #Workup
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... - APTT < 1.5 x normal ... #diagnosis #causes ... treatment #management #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
(DIC) Platelet ... platelet aggregation PT ... using INR use PT ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... ) ABNORMAL PT ... ABNORMAL PT/ ... #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... (DIC) c. ... #Causes #diagnosis ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... #Causes #diagnosis ... #differential #hematology ... #coagulation
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... also arise in normal ... Hepatosplenomegaly, cytopenias(bleeding ... #oncology #diagnosis ... #differential #hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... factors: PT/INR ... RBC (hemolysis, bleeding ... liver #chemistry #diagnosis ... #differential #Hepatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... blood cells appear normal ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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