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coagulation differential abnormal causes laboratory management prolonged pt algorithm bleeding bruising defects deficiencies dic disseminated druginduced hemostasis inherited intravascular lupus
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Investigation of Abnormal ... PT - Prolonged aPTT ... #Coagulation #Abnormal ... #Hematology #Diagnosis ... #Workup
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
clotting factor deficiency ... PT and/or aPTT) ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... amyloidosis #Abnormal ... #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Jcortesizaguirr #Abnormal ... #Causes #diagnosis ... #differential #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Hemophilia A - Deficiency ... Hemophilia B - Deficiency ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
thrombopoietin deficiency ... INR < 2.3 - APTT ... < 1.5 x normal ... #Coagulation #diagnosis ... treatment #management #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... • Immunologic Workup ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Normal ... a storage pool deficiency ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... performed PT, PTT ... levels - Usually normal ... products or D-dimer - Normal ... #Workup #Hematology
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