12 results
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
Rouleaux formation ... evemariecrane #Rouleaux ... #formation #IgM ... gammopathy #MGUS #Clinical ... #Pathology #Hematology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
with extensive rouleaux ... formation. ... #formation #Clinical ... #Smear #Hematology ... #Pathology
Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on
formation” wherein ... normal blood tends ... dilution with normal ... #Clinical #Pathology ... #Formation #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Diagnosis Algorithm Normal ... Anemia RBCs in Rouleaux ... Formation • Multiple ... WBCs - Normal ... Algorithm #Causes #Hematology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
fatigue, bone pain, abnormal ... bleeding) • Rouleaux ... formations noted ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Autoimmune diseases • Clinical ... also arise in normal ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... significant fibrin clot formation ... Thrombocytopenia - Normal ... - APTT < 1.5 x normal ... treatment #management #hematology
Megaloblastic neutrophils in bone marrow.

So-called "giant bands" and "giant metamyelocytes" (blue circles) are 1.5-2 times the
times the size of normal ... BoneMarrow #Smear #Hematology ... #Pathology #Clinical
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... syndrome (MDS) (normal ... megakaryocytes and a normal ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cooled from the normal ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Biopsy: Typical pathologic ... #hematology