13 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... to identify the cause ... ISNeducation #Abnormal ... #diagnosis #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... Pre-analytical cause ... e.g. heparin ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
the PT and the aPTT ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... amyloidosis #Abnormal ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia - Normal ... Treat primary cause ... < 1.5 x normal ... Coagulation #diagnosis #causes ... treatment #management #hematology
Etiologies of Hypoaldosteronism

Hyporeninemic Hypoaldosteronism (Low Renin, Low Aldosterone)
 - Diabetic Nephropathy 
 - NSAIDs
Non-Hyporeninemic Hypoaldosteronism (Normal
Hypoaldosteronism (Normal ... Inhibitors - Chronic heparin ... or High Renin, Normal ... #Aldosterone #Comparison ... #Table #Causes
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Dysplastic nodule, Hepatic ... Liver #Lesions #Hepatic ... differential #diagnosis #comparison ... #table #appearance ... #hepatology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Arterial Phase, Portal ... Liver #Lesions #Hepatic ... differential #diagnosis #comparison ... #table #appearance ... #hepatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... Acquired: • Heparin ... PT/NORMAL PTT: ... discern these causes
Common Vasopressors and Inotropes
Norepinephrine (NE)
 - Indication: Distributive shock (1st line for septic shock), Cardiogenic shock
(1st line for septic ... Bradyarrhythmias, Some cases ... of septic shock ... Vasopressors #Inotropes #comparison ... #table #pharmacology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
CRP - Usually normal ... Discontinuation of causal ... - CRP: Usually normal ... druginduced #lupus #sle #comparison ... #table #rheumatology