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diagnosis algorithm disease signs symptoms syndrome treatment workup adultonset approach arteritis arthritis behcet causes classification effusions gca giantcell gout hodgkins
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... Direct antiglobulin test ... hemosiderin • PT/aPTT normal ... #Diagnosis #Management ... #Algorithm #hematology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
- Differential ... Brucellosis - Viruses: HIV ... Effusions: - Hematologic ... - Synovium - Oral ... #diagnosis #msk
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... also arise in normal ... involvement Differential ... #NonHodgkins #comparison ... #hematology
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
Elevated ESR, Normal ... muscle weakness • Normal ... Myopathies #myopathy #differential ... #diagnosis #comparison ... #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Coxsackie, CMV, EBV, HIV ... CK, normal biopsy ... Disease #diagnosis #management ... #treatment #rheumatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
present both at rest ... e.g., congenital hip ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Positive pathergy test ... is a skin prick test ... Behcet disease) Differential ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Better call hematology ... exogenous, EPO levels: normal ... Best to have an ... Algorithm #workup #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
very remarkable w/differential ... 50 in GCA, but normal ... the “Chewing gum test ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Pharmacologic: • Severe oral ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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