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diagnosis hematology oncology lupus signs sle syndrome classification disease hemeonc syndromes systemic thrombocytopenia vasculitis agglutinin anemia antinuclear antinxp2 antinxp2dm apml
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... serial dilution ... context of other symptoms ... #rheumatology #diagnosis ... #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... SLE-Related Auto-Antibodies ... : - ANA 95-100% ... autoantibodies #signs #symptoms ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Induced Lupus: • Symptoms ... 1, SCL-70, RNP antibodies ... #Diagnosis #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... malignancies -> CLL ... younger pts) Differential ... hemolytic #anemia #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... Lymphocytes • Median ... lymphadenopathy and ... 3) Monoclonal antibodies ... hemeonc #diagnosis #management
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
MEDIUM VESSEL ... Presentation - Systemic Symptoms ... LFT • ESR • ANA ... ) pattern: antibodies ... #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... pylori test (GI symptoms ... anti-phospholipid antibodies ... not required in all ... Causes #Workup #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms ... Workup: - ANA ... Systemic Lupus Erythematosus ... comparison #table #rheumatology
Ear Pain (Otalgia) - Differential Diagnosis Framework Primary Otalgia - Pain that originates from the ear
Pain (Otalgia) - Differential ... Basal/squamous cell ... Relapsing, bilateral, erythematous ... symptoms: headache ... • Associated symptoms
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
EGPA) • Auto-antibodies ... or serologies + symptoms ... blood retum in serial ... Renal #Syndromes #differential ... #diagnosis #management
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