7 results
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Cystinuria - Amino acid ... ascending limb Gitelman ... tubular acidosis ... #Nephrology #Diagnosis ... #Differential #Table
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Losses: • Normal Acid-Base ... Metabolic acidosis ... , Gitelman syndrom ... Algorithm #causes #potassium ... #low #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
alkalosis • Normal/low ... , Gitelman syndrome ... gap metabolic acidosis ... of sodium and potassium ... #differential #diagnosis
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... alkalosis • Normal or low ... , Renal tubular ... acidosis (RTA)) ... #Syndrome #diagnosis
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
suggests extra-renal ... , Gitelman syndrome ... acidosis: Proximal ... #Hypokalemia #diagnosis ... #nephrology #low
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
: Differential Diagnosis ... chronic respiratory acidosis ... defect) • Thiazide ... furosemide-like lesion) • Gitelman ... other • Severe potassium
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Acidosis B. ... E-aminocaproic acid ... antiphospholipid syndrome ... #Differential #Diagnosis ... #High #Potassium