10 results
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Pregnancy - AFLP ... • Cholestatic disease ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
of cholestatic disease ... • Near normal ... : < 1 • Cirrhosis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... function may be abnormal ... : < 1 • Cirrhosis ... #differential # ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... obstruction • ALP ... bile ducts Differential ... Diagnosis: • Viral hepatitis ... diagnosis #workup #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... of Pregnancy (AFLP ... #Pregnancy #hepatology ... #obstetrics #hepatitis ... #comparison #differential
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites Normal ... - Cirrhosis ... - Alcoholic hepatitis ... Causes #diagnosis #differential ... #hepatology #SAAG
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... alcohol-related liver disease ... mellitus; USS, ultrasound ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
Primary Biliary Cirrhosis - Management
A. Initiate therapy 
 - Initiate 1st line therapy with UDCA (13-15
line therapy if ALP ... 1.5x ULN and/or abnormal ... complex: Artificial tears ... Stage & survey disease ... Management #Treatment #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
• Heavy chain disease ... : Cirrhosis, ETOH ... , autoimmune hepatitis ... chain assay • An abnormal ... Gap #ProteinGap #differential
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
advanced liver disease ... : cirrhosis, severe ... alcoholic hepatitis ... ultrasound ... Hepatorenal #Syndrome #Hepatology