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algorithm liver lfts transaminitis enzymes hepatocellular abnormal biliary chemistry cholangitis cholestatic cirrhosis elevation fatty interpretation liverenzymes management obgyn obstetrics ophthalmology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
disease • If ALP ... • Near normal ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... ALP: - Enzymes ... - Increased ALP ... Intestine - Other causes ... #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Enzymes (LFTs) - Causes ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis ... #differential # ... hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Vascular Causes ... GGT/5-NT: ↑ - ALP ... #hepatitis #differential ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
compared with alkaline ... Differential Diagnosis ... • Infections: Hepatitis ... Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Pregnancy - AFLP ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Hepatitis, Preeclampsia ... iMedEducation #AFLP
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... PBC Labs: • Alkaline ... obstruction • ALP ... Viral hepatitis, ... #workup #hepatology
Traumatic Red Eye - Differential Diagnosis Algorithm Surface Injury: • Corneal Abrasion • Ultraviolet Keratitis • Chemical
Diagnosis Algorithm ... • Ultraviolet Keratitis ... Chemical (Acid, alkali ... hemorrhage • Retina: Tear ... #Causes #Ophthalmology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... mellitus; USS, ultrasound ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential
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