12 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... ALP: - Enzymes ... - Increased ALP ... Intestine - Other causes ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
phos/ULN ALP) ... • Near normal ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
) - Causes of Hepatocellular ... + ULN ALT) / (alkaline ... Transaminitis #diagnosis ... #differential # ... hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential ... Vascular Causes ... GGT/5-NT: ↑ - ALP ... hemolysis) • ALP ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... infiltration) Differential ... Hepatitis, Preeclampsia ... iMedEducation #AFLP ... Pregnancy #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Pregnancy - AFLP ... • Alcoholic hepatitis ... Others #LFTs #Hepatology ... #Causes
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
in 1923 Low ALP ... synthesized in: liver ... Most cases diagnosed ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
compared with alkaline ... disproportionate increase in alkaline ... Infections: Hepatitis ... #Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase ... mellitus; USS, ultrasound ... Abnormal #Algorithm #Hepatology ... #Differential #
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... PBC Labs: • Alkaline ... obstruction • ALP ... Viral hepatitis, ... #workup #hepatology