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diagnosis hematology differential syndrome chronic cll leukemia lymphocytic mds myelodysplastic neurology aids anemia cardiology cardiotoxicity checkpoint classification cns differentiation hemeonc
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
mutations) • Immune ... anemia Treatment ... • Improve the symptoms ... #Anemia #oncology ... hematology #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
increase in CD4+ cells ... leukoencephalopathy (PML ... weeks for most OI ... #IRIS #Immune ... Differential #Diagnosis #Management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... risk-stratification • Risks: infection ... only curative treatment ... #treatment #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Diagnosis: >3 symptoms ... Differential Diagnosis: Infection ... #diagnosis #management ... #hematology #oncology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
• IRIS might ... less than 200 cells ... Antimicrobial treatment ... required until immune ... patients with IRIS
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... with no early symptoms ... weeks without infection ... Pure red cell aplasia ... microglobulin Treatment
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
lymphocytes, smudge cells ... Complications: 1) Infection ... transformation) Treatment ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Causes • Anemia • Aplastic ... Significance (IDUS) • Immune ... • Parvovirus infection ... diagnosis #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Erythema nodosum • Immune ... ingestion • B symptoms ... Hodgkin Lymphoma Treatment ... #management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
activation of an immune ... mediated disease • Immune ... Bilateral signs and/or symptoms ... Transverse Myelitis Treatment ... Myelitis #diagnosis #management
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