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hematology oncology differential leukemia pathophysiology chronic differentiation fever hemeonc hemophagocytic hlh immune inflammatory leukostasis lymphocytic lymphohistiocytosis lysis neurology ophthalmology palsy
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CLL Acute leukemias ... lymphadenopathy • Blast cells ... Rapidly rising blast cells ... : Granulocytic cells ... organs When Cancer Cells
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... cells can infiltrate ... smear: Smudge cells ... or basket cells
Retinoblastoma: Pathogenesis and clinical findings • Sporadic mutation -> One allele of RB1 tumor suppressor gene
cells -> Mutagenic ... / Symptoms / Complications ... detachment • Red Eye ... ophthalmology #diagnosis ... #signs #symptoms
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... : >3 symptoms, or ... #APML #diagnosis ... #management #hematology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host ->
Acute Rheumatic ... B and CD-4+ T cells ... pathophysiology #diagnosis ... #signs #symptoms ... #complications
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory Syndrome ... increase in CD4+ cells ... weeks for most OI ... #Inflammatory #Syndrome ... #Management
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy Presentation:
Bell's Palsy - Diagnosis ... GrepMed Handbook Acute ... ophthalmoplegia), systemic signs ... tears oint + TAPE eye ... within 4m #Bells
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- ACS, AKI, acute ... WBC >100k, + lab signs ... Lysis of tumor cells ... #TLS #diagnosis ... #management #hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... and Management ... tissue: Epithelioid cells ... : ACUTE, fever, ... #Management #Signs
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... Arthralgias • Eye ... purpura: Strong sign ... Multinucleated giant cells ... • Progressive symptoms
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