21 results
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
Inflammatory Syndrome ... increase in CD4+ cells ... weeks for most OI ... #Inflammatory #Syndrome ... #Management
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in all cells ... / Symptoms / Complications ... detachment • Red Eye ... ophthalmology #diagnosis ... #signs #symptoms
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
pain/pain upon eye ... pain • Extra-CNS complications ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Neurological Manifestations of Tuberculosis
Spinal Arachnoiditis & Polyradiculopathy:
 • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
Reconstitution Inflammatory Syndrome ... (IRIS): • In HIV ... • Usually is a complication ... • Caused by immune ... #Tuberculosis #diagnosis
Psoriatic Arthritis: Complications

 • Ocular - Inflammation of middle layer of the eye (the uvea, which
middle layer of the eye ... which includes the iris ... pathophysiology #diagnosis ... #signs #symptoms ... #Complications
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
rendering the immune ... with no early symptoms ... Physical Exam/Signs ... phenomenon CLL Diagnosis ... • Richter’s Syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
mutations) • Immune ... HCV - HIV • Immune ... • Improve the symptoms ... oncology #hematology #diagnosis ... #management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
: Inflammatory eye ... meningitis), MCC CNS symptoms ... Genital ulcers • Eye ... #diagnosis #management ... #signs #symptoms
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... WBC >100k, + lab signs ... Lysis of tumor cells ... #TLS #diagnosis ... #management #hematology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
cell-mediated immune ... - Formation of immune ... nephrotic/nephritic syndrome ... Pathophysiology #Diagnosis ... #Signs #Symptoms